Designing clinical trials on gastric lymphomas and reporting outcomes.
نویسندگان
چکیده
Additional cytogenetic changes do not influence the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with an ATRA plus anthracyclin based protocol. A report from the Spanish group PETHEMA Jesus María Hernández, Guillermo Martín, Norma Carmen Gutiérrez, José Cervera, María Teresa Ferro, María José Calasanz, José Angel Martínez-Climent, Elisa Luño, Mar Tormo, Consuelo Rayón, Joaquín Díaz-Mediavilla, Marcos González, José David González-San Miguel, Katy Pérez-Equiza, Concha Rivas, Jordi Esteve, Maria del Carmen Alvárez, Jesús Odriozola, José María Ribera, Miguel Angel Sanz for the PETHEMA Cooperative Group, Spain............807-813
منابع مشابه
درماتولوژی مبتنی بر شواهد: گزارش درست مقایسهی پیامدها در کارآزماییهای بالینی
According to evidence-based medicine, randomized controlled clinical trials are a group of research designs which provides the highest level of clinical evidence, particularly regarding therapeutic or preventive interventions. Considering the dramatic increase in the number of published clinical trials in medical journals, the readership need to have knowledge about the problems that may occur ...
متن کاملImportant considerations in calculating and reporting of sample size in randomized controlled trials
Background: The calculation of the sample size is one of the most important steps in designing a randomized controlled trial. The purpose of this study is drawing the attention of researchers to the importance of calculating and reporting the sample size in randomized controlled trials. Methods: We reviewed related literature and guidelines and discussed some important issues in s...
متن کاملStandardising the reporting of outcomes in gastric cancer surgery trials: protocol for the development of a core outcome set and accompanying outcome measurement instrument set (the GASTROS study)
BACKGROUND Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Whilst surgery is the mainstay of curative treatment, it is associated with significant risks. Surgical strategies for treating gastric cancer should be based on evidence from systematic reviews of well-designed randomised controlled trials. However, inconsistencies in the reporting of outcomes from these...
متن کاملBlindness in Randomized Controlled Trials
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
متن کاملWhy clinical trial outcomes fail to translate into benefits for patients
Clinical research should ultimately improve patient care. For this to be possible, trials must evaluate outcomes that genuinely reflect real-world settings and concerns. However, many trials continue to measure and report outcomes that fall short of this clear requirement. We highlight problems with trial outcomes that make evidence difficult or impossible to interpret and that undermine the tr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Haematologica
دوره 86 8 شماره
صفحات -
تاریخ انتشار 2001